Two and a half years after the dark day of the Lost JuLai, Meryl Stryfe roams in the desert wilderness of Noman's Land alongside her younger assistant, Milly Thompson. She still pursues Vash the Stampede, the culprit behind the cataclysmic events that took the lives of 90 percent of the JuLai city population. Vash, also referred to as the "Humanoid Typhoon," is now sought after for 60 billion double dollars—the largest bounty in the history of the planet.

In a backwater town of Noman's Land, an apathetic Vash has been rescued and cared for by Hoppered the Gauntlet, a man who covers his mutilated body with armor. But Hoppered's secluded life is abruptly interrupted by the arrival of young Jessica seeking help for her endangered home.

[Written by MAL Rewrite]